2ibs | pdb_00002ibs

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File:2ibs.png

Template:STRUCTURE 2ibs

Crystal structure of the adenine-specific DNA methyltransferase M.TaqI complexed with the cofactor analog AETA and a 10 bp DNA containing 2-aminopurine at the target position

Template:ABSTRACT PUBMED 17455934

About this Structure

2IBS is a 6 chains structure of sequences from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

  1. Lenz T, Bonnist EY, Pljevaljcic G, Neely RK, Dryden DT, Scheidig AJ, Jones AC, Weinhold E. 2-Aminopurine flipped into the active site of the adenine-specific DNA methyltransferase M.TaqI: crystal structures and time-resolved fluorescence. J Am Chem Soc. 2007 May 16;129(19):6240-8. Epub 2007 Apr 25. PMID:17455934 doi:https://dx.doi.org/10.1021/ja069366n
  2. Blumenthal RM, Cheng X. A Taq attack displaces bases. Nat Struct Biol. 2001 Feb;8(2):101-3. PMID:11175890 doi:https://dx.doi.org/10.1038/84072
  3. Schluckebier G, Kozak M, Bleimling N, Weinhold E, Saenger W. Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M.TaqI. J Mol Biol. 1997 Jan 10;265(1):56-67. PMID:8995524 doi:https://dx.doi.org/10.1006/jmbi.1996.0711

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