NS5B

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NS5B, the RNA Dependent RNA Polymerase from Hepatitis C Virus

PDB ID 2HAI

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File:1NB4 4domains.jpg

PDB IDs 2HAI (protein) 1RTD (DNA)

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NS5B with B form DNA from HIV Reverse Transcriptase co-crystal model. DNA was modeled in by alignment of palms domain. A beta hairpin in the thumb domain has been moved to accommodate DNA, the hairpin is modeled into the minor groove, a possible binding site.