Sandbox 72

Please do NOT make changes to this Sandbox until after April 30, 2009. Sandboxes 60-80 are reserved until then for use by students of East High, Buffalo NY.

A FIBRIN b

When you cut yourself, you bleed, but the bleeding rapidly stops. Blood has a built-in emergency repair system that quickly blocks any damage to the circulatory system, creating a temporary patch that allows time for more permanent repairs. Three basic mechanisms are at work. First, platelets (small fragments of blood cells that circulate in the blood) clump at the site of the wound, forming a weak plug. Second, neighboring blood vessels constrict, reducing the amount of blood flowing into the area. Finally, the protein fibrin assembles into a tough network that clots the blood and forms an insoluble blockage. Together, these methods stop the loss of blood and create a sturdy scab to protect the area as you heal.

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load and display another structure.

1m1j, resolution 2.70Å (default scene)

Ligands:

CA, NAG, NDG

Related:

1ei3, 1fzc

Structural annotation:
Resources:	CATH : 1M1Ja00, 1M1Jb02, 1M1Jb01, 1M1Jb03, 1M1Jc01, 1M1Jc02, 1M1Jc03, 1M1Jd00, 1M1Je01, 1M1Je03, 1M1Je02, 1M1Jf01, 1M1Jf02, 1M1Jf03 InterPro : Ipr012290, Ipr014716, Ipr014814, Ipr002181, Ipr014715 Pfam : PF08702, PF00147 SCOP : d1m1ja_, d1m1jf1, d1m1jf2 UniProt : P14448, Q02020, O93568

Functional annotation:
Cellular component:	fibrinogen complex
Biological process:	signal transduction blood coagulation platelet activation protein polymerization
Molecular function:	protein binding, bridging receptor binding