3gcw | pdb_00003gcw
From Proteopedia
PCSK9:EGFA(H306Y)
Template:ABSTRACT PUBMED 19224862
Disease
Known disease associated with this structure: Hypercholesterolemia, familial OMIM:[606945]
About this Structure
3GCW is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- McNutt MC, Kwon HJ, Chen C, Chen JR, Horton JD, Lagace TA. Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells. J Biol Chem. 2009 Apr 17;284(16):10561-70. Epub 2009 Feb 17. PMID:19224862 doi:10.1074/jbc.M808802200
Page seeded by OCA on Wed Apr 29 20:56:24 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Kwon, H J.
- Alternative splicing
- Autocatalytic cleavage
- Calcium
- Cholesterol metabolism
- Coated pit
- Disease mutation
- Egf-like domain
- Endocytosis
- Glycoprotein
- Host-virus interaction
- Hydrolase
- Ldl
- Ldl receptor
- Lipid metabolism
- Lipid transport
- Membrane
- Pcsk9
- Phosphoprotein
- Polymorphism
- Protease
- Protein binding
- Receptor
- Secreted
- Serine protease
- Steroid metabolism
- Transmembrane
- Transport
- Zymogen
