2reb | pdb_00002reb
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THE STRUCTURE OF THE E. COLI RECA PROTEIN MONOMER AND POLYMER
Overview
The crystal structure of the recA protein from Escherichia coli at 2.3-A, resolution reveals a major domain that binds ADP and probably single- and, double-stranded DNA. Two smaller subdomains at the N and C termini, protrude from the protein and respectively stabilize a 6(1) helical, polymer of protein subunits and interpolymer bundles. This polymer, structure closely resembles that of recA/DNA filaments determined by, electron microscopy. Mutations in recA protein that enhance coprotease, DNA-binding and/or strand-exchange activity can be explained if the, interpolymer interactions in the crystal reflect a regulatory mechanism in, vivo.
About this Structure
2REB is a Single protein structure of sequence from Escherichia coli. Active as Deleted entry, with EC number 3.4.99.37 Full crystallographic information is available from OCA.
Reference
The structure of the E. coli recA protein monomer and polymer., Story RM, Weber IT, Steitz TA, Nature. 1992 Jan 23;355(6358):318-25. PMID:1731246
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