2spc | pdb_00002spc
CRYSTAL STRUCTURE OF THE REPETITIVE SEGMENTS OF SPECTRIN
|
Overview
The elongated proteins of the spectrin family (dystrophin, alpha-actinin, and spectrin) contain tandemly repeated segments and form resilient, cellular meshworks by cross-linking actin filaments. The structure of one, of the repetitive segments of alpha-spectrin was determined at a 1.8, angstrom resolution. A segment consists of a three-helix bundle. A model, of the interface between two tandem segments suggests that hydrophobic, interactions between segments may constrain intersegment flexibility. The, helix side chain interactions explain how mutations that are known to, produce hemolytic anemias disrupt spectrin associations that sustain the, integrity of the erythrocyte membrane.
About this Structure
2SPC is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
Crystal structure of the repetitive segments of spectrin., Yan Y, Winograd E, Viel A, Cronin T, Harrison SC, Branton D, Science. 1993 Dec 24;262(5142):2027-30. PMID:8266097
Page seeded by OCA on Wed Nov 21 14:02:44 2007
