User:Jaime Prilusky/SequenceToStructure

spinqualitylabelsall models T0498 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

spinqualitylabelsall models T0499 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

A one-way street

A very basic axiom in Structural Bioinformatics states that a protein sequence has all the required information to fold and become a spatial structure. This sounds reasonable as long as a the same protein sequence, with no extra help, always assumes the same three dimensional configuration when folding. No external guidance. No errors. The sequence simply knows it's final destination.

In summary: multiple copies of the same protein sequence will always fold into the same 3D structure. Different protein sequences will, of course, fold into different spatial conformations.

This sounds like a clear one-way street example: from any given protein sequence you can obtain one, and only one structure.

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Jaime Prilusky