Sandbox1313

Lysyl-tRNA Synthase

Shown here is PDB number 1bbu, lysyl-tRNA Synthase shown here complexed with the lysine substrate. It consists of both "α-helices" and "β-strands" (the latter in sheets and a barrel).

As you can see in the "active site", the lysine participates in multiple "hydrogen bonding interactions" to stay complexed to the synthase protein as it moves into position to build the tRNA in the ribosome.

It is also worth mentioning that when the lysine enters the complex, a small number of "residues" trigger a

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1bbw, resolution 2.70Å (default scene)
Gene:	LYSS (Escherichia coli)
Activity:	Lysine--tRNA ligase, with EC number 6.1.1.6
Related:	1bbu
Structural annotation: Resources: CATH : 1Bbwa02, 1Bbwa01 InterPro : Ipr004364, Ipr006195, Ipr002313, Ipr012340, Ipr004365 Pfam : PF01336, PF00152 SCOP : d1bbwa2, d1bbwa1 UniProt : P0A8N3
Functional annotation: Cellular component: membrane fraction cytoplasm Biological process: tRNA aminoacylation for protein translation translation lysyl-tRNA aminoacylation Molecular function: nucleotide binding ATP binding metal ion binding aminoacyl-tRNA ligase activity magnesium ion binding ligase activity protein binding nucleic acid binding lysine-tRNA ligase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml