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Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8

By Amit Shavit

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='1pq2' size='350' frame='false' scene=
3cin, resolution 1.70Å (default scene)
Ligands:	CL, MG, NAD
Gene:	TM1419, TM_1419 (Thermotoga maritima MSB8)
Activity:	Inositol-3-phosphate synthase, with EC number 5.5.1.4
Structural annotation: Resources: CATH : 3Cina01, 3Cina02 InterPro : Ipr016040, Ipr013021, Ipr002587 Pfam : PF07994
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum, TOPSAN
Coordinates:	save as pdb, mmCIF, xml

Protein

Active Sites are shown in brown

Structure

Beta Sheet are portrayed in purple.

Alpha Helices are portrayed in blue

Hydrophobic interactions in red

Polar bonds in dark green

Reference

Schoch GA, Yano JK, Wester MR, Griffin KJ, Stout CD, Johnson EF Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site. J Biol Chem. 2004 Mar 5;279(10):9497-503. Epub 2003 Dec 15. PMID:14676196