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Glucokinase
The shown representation is a DNA:RAN hybrid duplex. This is the DNA in orange and this is the RNA in green. We can choose to see the base pairs, which show very neatly. First, the G-C pairs: dG-C are in blue and dC-G are in yellow.
Structure
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| 1v4s, resolution 2.30Å (default scene) | |||||||||||||
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| Ligands: | GLC, MRK, NA | ||||||||||||
| Activity: | Hexokinase, with EC number 2.7.1.1 | ||||||||||||
| Related: | 1v4t | ||||||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
The glucokinase has 18 alpha helices (unless we counted wrong), 13 beta sheets (this one is for sure), and 3 ligands: a sodium ion, T2 amino-4-fluoro-5-[(1-methyl-1h-amidazol-2-yl)sulfanyl]-n-(1,3-thiazol-2-yl)benzamide amide or MRK in short, and last a sugar (alpha-d-glucose) or simply GLC.
Purple denotes all the polar sections of the protein: the hydrophillic areas that dominate the outer surface which comes in contact with aqueous environments. In this view we can see very neatly how the beta sheets alternate in polarity in a 'zigzag manner, and how the alpha helices are roughly 2-3 polar (while the inner protein is obviously hydrophobic). The spacefill representation, in particular, shows how the surface is dominantly hydrophillic.
Reference
https://www.proteopedia.org/wiki/index.php/1v4s https://en.wikipedia.org/wiki/Glucokinase
--Tinuke (Abike etc. etc. etc.) Adeyemi and Niva Ran
