3eta | pdb_00003eta
From Proteopedia
Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor
Disease
Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[147670], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[147670], Leprechaunism OMIM:[147670], Rabson-Mendenhall syndrome OMIM:[147670]
About this Structure
3ETA is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Patnaik S, Stevens KL, Gerding R, Deanda F, Shotwell JB, Tang J, Hamajima T, Nakamura H, Leesnitzer MA, Hassell AM, Shewchuck LM, Kumar R, Lei H, Chamberlain SD. Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3136-40. Epub 2009 Jan 6. PMID:19394223 doi:10.1016/j.bmcl.2008.12.110
Page seeded by OCA on Wed May 27 15:20:32 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Receptor protein-tyrosine kinase
- Chamberlain, S.
- Deanda, F.
- Gerding, R.
- Hamajima, T.
- Hassell, A.
- Kumar, R.
- Leesnitzer, A.
- Lei, H.
- Nakamura, H.
- Patnaik, S.
- Shewchuk, L.
- Shotwell, B.
- Stevens, K.
- Tang, J.
- Alternative splicing
- Atp-binding
- Carbohydrate metabolism
- Cleavage on pair of basic residue
- Diabetes mellitus
- Disease mutation
- Glycoprotein
- Kinase
- Membrane
- Nucleotide-binding
- Phosphoprotein
- Polymorphism
- Receptor
- Signaling protein
- Transferase
- Transmembrane
- Tyrosine-protein kinase
