2k9r | pdb_00002k9r
From Proteopedia
Enhancing the activity of insulin by stereospecific unfolding
Disease
Known disease associated with this structure: Hyperproinsulinemia, familial, with or without diabetes OMIM:[176730]
About this Structure
2K9R is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Hua QX, Xu B, Huang K, Hu SQ, Nakagawa S, Jia W, Wang S, Whittaker J, Katsoyannis PG, Weiss MA. Enhancing the activity of a protein by stereospecific unfolding: conformational life cycle of insulin and its evolutionary origins. J Biol Chem. 2009 May 22;284(21):14586-96. Epub 2009 Mar 25. PMID:19321436 doi:10.1074/jbc.M900085200
Page seeded by OCA on Wed Jun 10 16:32:05 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Hu, S Q.
- Hua, Q X.
- Huang, K.
- Jia, W H.
- Katsoyannis, P G.
- Nakarawa, S.
- Philips, N F.P.
- Weiss, M A.
- Wittaker, J.
- Wittaker, L.
- Xu, B.
- Carbohydrate metabolism
- Cleavage on pair of basic residue
- Diabetes mellitus
- Disease mutation
- Glucose metabolism
- Hormone
- Insulin
- Mutant
- Pharmaceutical
- Secreted
