1e50 | pdb_00001e50

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File:1e50.png

Template:STRUCTURE 1e50

AML1/CBF COMPLEX

Template:ABSTRACT PUBMED 10856244

Disease

Known disease associated with this structure: Leukemia, acute myeloid OMIM:[151385], Platelet disorder, familial, with associated myeloid malignancy OMIM:[151385], Rheumatoid arthritis, susceptibility to OMIM:[151385], Myeloid leukemia, acute, M4Eo subtype OMIM:[121360]

About this Structure

1E50 is a 10 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Warren AJ, Bravo J, Williams RL, Rabbitts TH. Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta. EMBO J. 2000 Jun 15;19(12):3004-15. PMID:10856244 doi:10.1093/emboj/19.12.3004

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