3gw5 | pdb_00003gw5
From Proteopedia
Crystal structure of human renin complexed with a novel inhibitor
Template:ABSTRACT PUBMED 19457666
Disease
Known disease associated with this structure: Renal tubular dysgenesis OMIM:[179820], Hyperproreninemia OMIM:[179820]
About this Structure
3GW5 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Tice CM, Xu Z, Yuan J, Simpson RD, Cacatian ST, Flaherty PT, Zhao W, Guo J, Ishchenko A, Singh SB, Wu Z, Scott BB, Bukhtiyarov Y, Berbaum J, Mason J, Panemangalore R, Cappiello MG, Muller D, Harrison RK, McGeehan GM, Dillard LW, Baldwin JJ, Claremon DA. Design and optimization of renin inhibitors: Orally bioavailable alkyl amines. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3541-5. Epub 2009 May 5. PMID:19457666 doi:10.1016/j.bmcl.2009.04.140
Page seeded by OCA on Thu Jun 25 09:04:36 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Renin
- McKeever, B M.
- Wu, Z.
- Alternative splicing
- Aspartate protease
- Aspartyl protease
- Cleavage on pair of basic residue
- Crystal structure
- Disease mutation
- Disulfide bond
- Glycoprotein
- Hydrolase
- Hydrolase/hydrolase inhibitor complex
- Hypertension
- Membrane
- Polymorphism
- Protease
- Renin expression
- Renin inhibitor
- Secreted
- Zymogen
