1s9b | pdb_00001s9b
Crystal Structure Analysis of the B-DNA GAATTCG
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Overview
DNA oligonucleotides can be used in order to assemble highly structured, materials. Oligonucleotides with sticky ends can form long linear, structures, whereas branching is required to form two- and, three-dimensional nanostructures. In this paper, we show that when Ni(2+), is attached to the N7 atom of guanine, it can also act as a branching, point. Thus, we have found that the heptanucleotide d(GAATTCG) can, assemble into long linear duplex structures, which cross in space to, generate a cubic structure. The three-dimensional arrays are stabilized by, phosphate-Ni(2+)-guanine interactions. For the first time, the, crystallization of a B form DNA oligonucleotide in a cubic system is, reported, space group I23. Large solvent cavities are found among the DNA, duplexes.
About this Structure
1S9B is a Protein complex structure of sequences from [1] with NI as ligand. Full crystallographic information is available from OCA.
Reference
A cubic arrangement of DNA double helices based on nickel-guanine interactions., Valls N, Uson I, Gouyette C, Subirana JA, J Am Chem Soc. 2004 Jun 30;126(25):7812-6. PMID:15212528
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