1jux | pdb_00001jux
1.6A Resolution Crystal Structures of the DNA Octamers d(IUATATAC) and d(ITITACAC):Binding of Two Distamycin Drugs Side-by-Side
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Overview
The crystal structure of the DNA octamer d(ITITACAC)(2) complexed with, distamycin has been determined at 1.6 A resolution and refined to a final, R(work) and R(free) of 17.0 and 20.7%, respectively. Two molecules of, distamycin bind to the DNA duplex in an antiparallel side-by-side fashion., Each drug molecule covers five base pairs of the DNA duplex, with its, amide groups hydrogen-bonding to bases in the proximal DNA strand. These, two antiparallel drug molecules are stacked together with the pyrrole, rings of one molecule stacking against the amide groups of the other. The, present structure emphasizes the features of alternating DNA octamers in, interaction with distamycin.
About this Structure
1JUX is a Protein complex structure of sequences from [1] with DMY as ligand. Full crystallographic information is available from OCA.
Reference
Structure of d(ITITACAC) complexed with distamycin at 1.6 A resolution., Deng J, Pan B, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2342-4. Epub 2003, Nov 27. PMID:14646114
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