1b1v

NMR STRUCTURE OF PSP1, PLASMATOCYTE-SPREADING PEPTIDE FROM PSEUDOPLUSIA INCLUDENS

spinqualitylabelsall models 1b1v Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1b1v is a 1 chain structure with sequence from Chrysodeixis includens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 30 models Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PSP1_CHRIL Mediates the spreading of plasmatocytes to foreign surfaces. Plasmocytes are a class of hemocytes involved in insect cellular immunity. Publication Abstract from PubMed The structure of the recently identified plasmatocyte spreading peptide from the moth Pseudoplusia includens (PSP1) has been determined by NMR spectroscopy. This novel insect cytokine consists of 23 amino acid residues and a single disulfide bond. Torsion angle dynamics calculations utilizing a total of 337 distance constraints yielded an ensemble of 30 structures with an average backbone root mean square deviation for residues 7-22 of 0.18 A from the mean structure. The structure consists of a disordered N-terminal region and a well defined core that is stabilized by numerous hydrophobic interactions and a short beta-hairpin. Structural comparisons confirm that PSP1 adopts an epidermal growth factor (EGF)-like fold with close similarity to the C-terminal subdomain of EGF-like module 5 of human thrombomodulin. The combination of the three-dimensional structure of PSP1 and the extensive literature on EGF-receptor interactions should accelerate the process of identifying the specific residues responsible for receptor binding activity of this family of immunoregulatory peptides. Structure of the insect cytokine peptide plasmatocyte-spreading peptide 1 from Pseudoplusia includens.,Volkman BF, Anderson ME, Clark KD, Hayakawa Y, Strand MR, Markley JL J Biol Chem. 1999 Feb 19;274(8):4493-6. PMID:9988679 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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