1nav | pdb_00001nav

Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1

spinqualitylabelsall models 1nav, resolution 2.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1nav is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.5Å Ligands: IH5, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease THA_HUMAN Defects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:614450. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance. Function THA_HUMAN Nuclear hormone receptor. High affinity receptor for triiodothyronine. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Thyroid hormone receptor 3D structures

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