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2dm3

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Solution structure of the second ig domain of human palladin

Structural highlights

2dm3 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Disease

PALLD_HUMAN Familial pancreatic carcinoma. Disease susceptibility is associated with variants affecting the gene represented in this entry. Genetic variations in PALLD may be associated with susceptibility to myocardial infarction.^[1]

Function

PALLD_HUMAN Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci.^[2] ^[3] ^[4]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Shiffman D, Ellis SG, Rowland CM, Malloy MJ, Luke MM, Iakoubova OA, Pullinger CR, Cassano J, Aouizerat BE, Fenwick RG, Reitz RE, Catanese JJ, Leong DU, Zellner C, Sninsky JJ, Topol EJ, Devlin JJ, Kane JP. Identification of four gene variants associated with myocardial infarction. Am J Hum Genet. 2005 Oct;77(4):596-605. PMID:16175505 doi:10.1086/491674
↑ Mykkänen OM, Grönholm M, Rönty M, Lalowski M, Salmikangas P, Suila H, Carpén O. Characterization of human palladin, a microfilament-associated protein. Mol Biol Cell. 2001 Oct;12(10):3060-73. PMID:11598191 doi:10.1091/mbc.12.10.3060
↑ Rönty M, Taivainen A, Moza M, Otey CA, Carpén O. Molecular analysis of the interaction between palladin and alpha-actinin. FEBS Lett. 2004 May 21;566(1-3):30-4. PMID:15147863 doi:10.1016/j.febslet.2004.04.006
↑ Rönty M, Taivainen A, Heiska L, Otey C, Ehler E, Song WK, Carpen O. Palladin interacts with SH3 domains of SPIN90 and Src and is required for Src-induced cytoskeletal remodeling. Exp Cell Res. 2007 Jul 15;313(12):2575-85. PMID:17537434 doi:10.1016/j.yexcr.2007.04.030