2lwk

Solution structure of small molecule-influenza RNA complex

spinqualitylabelsall models 2lwk Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2lwk is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Ligands: 0EC Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA-DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits antiviral activity against influenza viruses. A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.,Lee MK, Bottini A, Kim M, Bardaro MF Jr, Zhang Z, Pellecchia M, Choi BS, Varani G Chem Commun (Camb). 2014 Jan 11;50(3):368-70. doi: 10.1039/c3cc46973e. Epub 2013 , Nov 18. PMID:24247110 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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