37on | pdb_000037on

Crystal structure of the Mucin-type O-glycosyltransferase PGANT5A-4M (A430T, L434N, A437N, S456Y)

spinqualitylabelsall models 37on, resolution 3.08Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 37on is a 4 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.08Å Ligands: BMA, EDO, GOL, MAN, MN, NAG, PG4, UDP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function GALT5_DROME Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:12829714, PubMed:18669915). It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Prefers EA2 as substrate (PubMed:12829714). In the larval midgut, required for O-glycosylation of apical and luminal proteins within copper cells enabling proper gut acidification (PubMed:22157008).

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