4zgv

The Crystal Structure of the Ferredoxin Receptor FusA from Pectobacterium atrosepticum SCRI1043

spinqualitylabelsall models 4zgv, resolution 3.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4zgv is a 2 chain structure with sequence from Pectobacterium atrosepticum SCRI1043. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.2Å Ligands: BOG, LDA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q6D8U4_PECAS Publication Abstract from PubMed Iron is a limiting nutrient in bacterial infection putting it at the centre of an evolutionary arms race between host and pathogen. Gram-negative bacteria utilize TonB-dependent outer membrane receptors to obtain iron during infection. These receptors acquire iron either in concert with soluble iron-scavenging siderophores or through direct interaction and extraction from host proteins. Characterization of these receptors provides invaluable insight into pathogenesis. However, only a subset of virulence-related TonB-dependent receptors have been currently described. Here we report the discovery of FusA, a new class of TonB-dependent receptor, which is utilized by phytopathogenic Pectobacterium spp. to obtain iron from plant ferredoxin. Through the crystal structure of FusA we show that binding of ferredoxin occurs through specialized extracellular loops that form extensive interactions with ferredoxin. The function of FusA and the presence of homologues in clinically important pathogens suggests that small iron-containing proteins represent an iron source for bacterial pathogens. Structure of the bacterial plant-ferredoxin receptor FusA.,Grinter R, Josts I, Mosbahi K, Roszak AW, Cogdell RJ, Bonvin AM, Milner JJ, Kelly SM, Byron O, Smith BO, Walker D Nat Commun. 2016 Oct 31;7:13308. doi: 10.1038/ncomms13308. PMID:27796364 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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