5hm2

Crystal structure of the 3C protease from South African Territories type 2 foot-and-mouth disease virus

spinqualitylabelsall models 5hm2, resolution 3.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5hm2 is a 5 chain structure with sequence from Foot-and-mouth disease virus SAT 2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.2Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function X5CZS0_9PICO Publication Abstract from PubMed The replication of foot-and-mouth disease virus (FMDV) is dependent on the virus-encoded 3C protease (3C(pro)). As in other picornaviruses, 3C(pro) performs most of the proteolytic processing of the polyprotein expressed from the large open reading frame in the RNA genome of the virus. Previous work revealed that the 3C(pro) from serotype A-one of the seven serotypes of FMDV-adopts a trypsin-like fold. On the basis of capsid sequence comparisons the FMDV serotypes are grouped into two phylogenetic clusters, with O, A, C, and Asia 1 in one, and the three Southern African Territories serotypes, (SAT-1, SAT-2 and SAT-3) in another, a grouping pattern that is broadly, but not rigidly, reflected in 3C(pro) amino acid sequences. We report here the cloning, expression and purification of 3C proteases from four SAT serotype viruses (SAT2/GHA/8/91, SAT1/NIG/5/81, SAT1/UGA/1/97, and SAT2/ZIM/7/83) and the crystal structure at 3.2 A resolution of 3C(pro) from SAT2/GHA/8/91. Crystal structure of the 3C protease from Southern African Territories type 2 foot-and-mouth disease virus.,Yang J, Leen EN, Maree FF, Curry S PeerJ. 2016 Apr 26;4:e1964. doi: 10.7717/peerj.1964. eCollection 2016. PMID:27168976 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Proteinase 3D structures Virus protease 3D structures

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