5zcy

Crystal structure of archaeal translation initiation factor 1 at 1.5 Angstroms resolution

spinqualitylabelsall models 5zcy, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5zcy is a 1 chain structure with sequence from Pyrococcus horikoshii OT3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.5Å Ligands: NO2, NO3 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SUI1_PYRHO Publication Abstract from PubMed The archaeal translation initiation factor 1 (aIF1) is reported to be functionally homologous to the eukaryotic translation initiation factor 1 (eIF1). However, lack of a structural comparison between aIF1 and eIF1 has limited our understanding of the structural (dis)similarities. Herein, we have determined the three-dimensional crystal structure of an open reading frame PH1771.1 encoding aIF1 in Pyrococcus horikoshii OT3. Results reveal that although aIF1 has low sequence similarity with eIF1, high structural homology exists between the two proteins. Nonetheless, notable critical differences between aIF1 and eIF1 could still be perceived at the beta1 -beta2 basic loop, the acidic loop and the solvent-exposed surface. These differences might lead to a slightly divergent mode of action of aIF1 during archaeal translation initiation. Archaeal and eukaryal translation initiation factor 1 differ in their RNA interacting loops.,Gogoi P, Kanaujia SP FEBS Lett. 2018 Apr 2. doi: 10.1002/1873-3468.13044. PMID:29608219 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Proteopedia Page Contributors and Editors (what is this?)

OCA