6akd

Crystal structure of IdnL7

spinqualitylabelsall models 6akd, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6akd is a 1 chain structure with sequence from Streptomyces sp. ML694-90F3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.1Å Ligands: A5A, GOL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A077KUW8_9ACTN Publication Abstract from PubMed Adenylation enzymes play an important role in the selective incorporation of the cognate carboxylate substrates in natural product biosynthesis. Here, the biochemical and structural characterization of the adenylation enzyme IdnL7, which is involved in the biosynthesis of the macrolactam polyketide antibiotic incednine, is reported. Biochemical analysis showed that IdnL7 selects and activates several small amino acids. The structure of IdnL7 in complex with an L-alanyl-adenylate intermediate mimic, 5'-O-[N-(L-alanyl)sulfamoyl]adenosine, was determined at 2.1 A resolution. The structure of IdnL7 explains the broad substrate specificity of IdnL7 towards small L-amino acids. Functional and structural characterization of IdnL7, an adenylation enzyme involved in incednine biosynthesis.,Cieslak J, Miyanaga A, Takaishi M, Kudo F, Eguchi T Acta Crystallogr F Struct Biol Commun. 2019 Apr 1;75(Pt 4):299-306. doi:, 10.1107/S2053230X19002863. Epub 2019 Apr 2. PMID:30950831 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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