6cjd | pdb_00006cjd

NMR Structure of Salmonella Type III Secretion system protein OrgC

spinqualitylabelsall models 6cjd Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6cjd is a 1 chain structure with sequence from Salmonella enterica subsp. enterica. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A0H3NF83_SALTS Publication Abstract from PubMed Type III protein secretion systems (T3SS) are encoded by several pathogenic or symbiotic bacteria. The central component of this nanomachine is the needle complex. Here we show in a Salmonella Typhimurium T3SS that assembly of the needle filament of this structure requires OrgC, a protein encoded within the T3SS gene cluster. Absence of OrgC results in significantly reduced number of needle substructures but does not affect needle length. We show that OrgC is secreted by the T3SS and that exogenous addition of OrgC can complement a orgC mutation. We also show that OrgC interacts with the needle filament subunit PrgI and accelerates its polymerization into filaments in vitro. The structure of OrgC shows a novel fold with a shared topology with a domain from flagellar capping proteins. These findings identify a novel component of T3SS and provide new insight into the assembly of the type III secretion machine. A protein secreted by the Salmonella type III secretion system controls needle filament assembly.,Kato J, Dey S, Soto JE, Butan C, Wilkinson MC, De Guzman RN, Galan JE Elife. 2018 Jul 17;7. pii: 35886. doi: 10.7554/eLife.35886. PMID:30015613 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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