6gcs | pdb_00006gcs

Cryo-EM structure of respiratory complex I from Yarrowia lipolytica

Loading... Status: waiting for Mol* initialization Structural highlights 6gcs is a 10 chain structure with sequence from Yarrowia lipolytica. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.32Å Ligands: 3PE, CDL, FES, FMN, NDP, ZMP, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9UUU3_YARLL Publication Abstract from PubMed Mitochondrial complex I has a key role in cellular energy metabolism, generating a major portion of the proton motive force that drives aerobic ATP synthesis. The hydrophilic arm of the L-shaped ~1 MDa membrane protein complex transfers electrons from NADH to ubiquinone, providing the energy to drive proton pumping at distant sites in the membrane arm. The critical steps of energy conversion are associated with the redox chemistry of ubiquinone. We report the cryo-EM structure of complete mitochondrial complex I from the aerobic yeast Yarrowia lipolytica both in the deactive form and after capturing the enzyme during steady-state activity. The site of ubiquinone binding observed during turnover supports a two-state stabilization change mechanism for complex I. Cryo-EM structure of respiratory complex I at work.,Parey K, Brandt U, Xie H, Mills DJ, Siegmund K, Vonck J, Kuhlbrandt W, Zickermann V Elife. 2018 Oct 2;7. pii: 39213. doi: 10.7554/eLife.39213. PMID:30277212 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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