8e06

Symmetry expansion of dimeric LRRK1

spinqualitylabelsall models 8e06, resolution 4.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8e06 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.3Å Ligands: GDP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease LRRK1_HUMAN Osteosclerotic metaphyseal dysplasia. The disease is caused by variants affecting the gene represented in this entry. Function LRRK1_HUMAN Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts.[UniProtKB:Q3UHC2] See Also Serine/threonine protein kinase 3D structures

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