8ikd | pdb_00008ikd

Structure of DNA binding domain of McrBC endonuclease bound to DNA: Y41F-L68Y double mutant

Loading... Status: waiting for Mol* initialization Structural highlights 8ikd is a 4 chain structure with sequence from DNA molecule and Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.1Å Ligands: BTB Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MCRB_ECOLI Recognizes N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines) produced by a broad range of DNA methylases and appears to act against 5-methylcytosine preceded by a purine residue. Binds to DNA containing methylated cytosines; also binds to GTP. Isoform 33 kDa is less active than isoform 51 kDa and may play a role in regulating the activity of isoform 51 kDa by competing with it in DNA and protein binding abilities.

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