8srz

Structure of a bacterial death-like domain from Lysobacter enzymogenes

spinqualitylabelsall models 8srz, resolution 1.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8srz is a 2 chain structure with sequence from Lysobacter enzymogenes. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.25Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PROT2_LYSEN Possibly a dedicated protease for substrate gasdermin bGSDM; cleaves the bGSDM precursor, releasing the pore-forming moiety, which integrates into the membrane and triggers cell death. Involved in defense against bacteriophages. When this probable 4 gene operon (bGSDM-FE772_23060-FE772_23065-FE772_23070) is inserted into E.coli it provides nearly 100-fold protection against phages T5 and T6 and about 8-fold against phage T4. The operon without bGSDM no longer protects against phage.

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