8vvc

Cryo-EM structure of human ABC transporter (hABCC1) with nucleotide-binding domain 2

spinqualitylabelsall models 8vvc, resolution 4.32Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8vvc is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.32Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MRP1_HUMAN Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.

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