| Structural highlights
9f40 is a 4 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Method: | X-ray diffraction, Resolution 2.44Å |
| Ligands: | BMA, CCN, ERG, MAN, NAG, PEG, SO4, ZN |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
NPC1_YEAST Involved in sphingolipid trafficking. May recycle sphingolipids between cellular membranous compartments.[1] [2]
References
- ↑ Malathi K, Higaki K, Tinkelenberg AH, Balderes DA, Almanzar-Paramio D, Wilcox LJ, Erdeniz N, Redican F, Padamsee M, Liu Y, Khan S, Alcantara F, Carstea ED, Morris JA, Sturley SL. Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution. J Cell Biol. 2004 Feb 16;164(4):547-56. PMID:14970192 doi:https://dx.doi.org/10.1083/jcb.200310046
- ↑ Berger AC, Hanson PK, Wylie Nichols J, Corbett AH. A yeast model system for functional analysis of the Niemann-Pick type C protein 1 homolog, Ncr1p. Traffic. 2005 Oct;6(10):907-17. PMID:16138904 doi:https://dx.doi.org/TRA327
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