9yvv

Structural highlights

Function

BMP7_MARM1 Cytochrome P450 protein involved in the biosynthesis of polybrominated aromatic organic compounds (PubMed:25061970). In the presence of ferredoxin, ferredoxin reductase and NADH, catalyzes the coupling of bromophenols and bromopyrroles, forming various polybrominated biphenyls and hydroxylated polybrominated diphenyl ethers (OH-BDE) (By similarity). Can also mediate the heterocoupling of 3,5-dibromocatechol, forming six different compounds, including polybrominated dibenzo-p-dioxins, which are among the most toxic molecules known to man (PubMed:25061970).[UniProtKB:V4HJ73]^[1]

References

1. ↑ Agarwal V, Moore BS. Enzymatic synthesis of polybrominated dioxins from the marine environment. ACS Chem Biol. 2014 Sep 19;9(9):1980-4. PMID:25061970 doi:10.1021/cb5004338