Alpha-glucosidase

spinqualitylabelsall models Structure of yeast isomaltase complex withα-D-glucose and Ca+2 ion (green) (PDB code 3a4a). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Alpha glucosidase (AGS) or maltase breaks down the 1,4-α bonds in starch or disaccharides to produce glucose. Maltase breaks down maltose. Isomaltase or sucrase-isomaltase or oligo-1,6-glucosidase breaks the 1,6 bond. Maltase-glucoamylase has important role in glucose production. It hydrolize linear alpha-1,4-linked oligosaccharides. Acid-alpha gucosidase degrades glycogen polymers to glucose in the acidic lysosomes. 6-phospho-alpha gucosidase hydrolyses maltose-6"-phosphate. Glucan 1,4-alpha gucosidase hydrolyses the terminal 1,4-linked alpha-D-glucose residues in polysaccharides to produce beta-glucose. For details see Sucrase-isomaltase. See also Kennedy research and Carbohydrate Metabolism. Disease AGS deficiency is the cause of Pompe Disease. AGS inhibitors are used as anti-diabetic drugs and can potentially prevent the fusion of HIV and hepatitis B virus to cells. Structural highlights α-D-glucose binding site (PDB code 3a4a). Water molecules shown as red spheres. Ca coordination site. 3D structures of α-glucosidase Alpha-glucosidase 3D structures

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