Inorganic pyrophosphatase

spinqualitylabelsall models Inorganic pyrophosphatase complex with pyrophosphate, 2bqy Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Inorganic pyrophosphatase (PPase) catalyzes the breakdown of pyrophosphate (PPi) to two molecules of phosphate (PO4). The reaction releases energy and is irreversible hence it is coupled to biochemical reactions which need to be driven to completion. PPase plays a role in lipid metabolism, calcium absorption, bone formation and DNA synthesis. PPase requires a divalent metal ion like Mg+2 for higher activity. PPi is formed in many biosynthetic reactions which require ATP. NADH pyrophosphatase catalyzes the hydrolysis of the phosphate bond of NADH to reduced mononucleotide. proton pyrophosphatase functions in the regulation of pyrophosphates in plants. Enhanced expression increases yields in crops. Structural highlights The biological assembly of Inorganic pyrophosphatase Helicobacter pylori is homohexamer. PPase binding pocket has electrostatic potential and is composed of 3 lysine residues, a tyrosine and several water molecules. Anionic (-) / Cationic (+). Water molecules shown as red spheres. 3D structures of inorganic pyrophosphatase Inorganic pyrophosphatase 3D structures

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