The following cyclic nucleotides have been tested in FirstGlance version 2.8 and are believed to be handled correctly: - They are reported as "unusual" in an alert at the outset of a session. - When the red U (for Unusual) below the molecule is clicked, they are "found" (yellow halos applied) in the "Find" dialog. - "Find" reports the found atoms correctly including the number of amino acid alpha carbons, the number of C5' atoms in nucleosides or nucleotides, and the number of Ligand+ atoms. EXAMPLES OF CYCLIC NUCLEOTIDES $ means tested successfully in FirstGlance version 2.8. //$ CYCLIC AMP "CMP" IN 5KJX: P CONNECTED TO O3' AND O5' (6 ATOM RING) 1 group //$ CYCLIC GMP "PCG" IN 5C8W: PA CONNECTED TO O3' AND O5' (6 ATOM RING) 6 groups //$ CYCLIC AMP "ACK" IN 2YPE: P CONNECTED TO O2' AND O3' (5 ATOM RING) 1 group //$ CYCLIC AM MONOPHOSPHOROTHIOATE "SP1" IN 3CF6: 3' AND 5'. 2 GROUPS //$ SIMILAR "RP1" IN 1NE4. 2 GROUPS. //$ "GPX" IN 1VJ7, CYCLIC GDP (3 P'S), 2' 3'. 1 GROUP. //$ "35G" IN 1BHN, CYCLIC GMP, 6 GROUPS + 6 GDPs. //$ "CCC" in 6dls, cyclic 2'3' CDP, 5' phosphate, 1 group with two phosphorus atoms. //$ "A23" in 1jbr, cyclic 2'3' ADP, 5' phosphate, 1 group with two phosphorus atoms. //$ "23G" in 5h9f, GUANOSINE-5'-PHOSPHATE-2',3'-CYCLIC PHOSPHATE //$ "6SZ" in 5khk, 2-Aminopurine riboside-3',5'-cyclic monophosphate //$ "6SX" in 5khi, Purine riboside-3',5'-cyclic monophosphate EXAMPLES OF CYCLIC NUCLEOTIDES WITH CYCLIZED DIPHOSPHATES These are seen by FirstGlance only as "single nucleoTides, not in a chain of standard nucleotides" FirstGlance does not look for, nor report, cyclized diphosphates. //$ "CXR" in 2o3q, cyclic adenosine diphosphate-ribose (two riboses), 1 group. CYCLIC NUCLEOTIDES NOT REPORTED AS UNUSUAL These are not recognized as nucleic (nor as RNA) by JSmol. Atoms that define nucleic in JSmol are all 9 of: C2, C3', C4, C5, C6, N1, N3, O3', O5' (JSmol atom names: %a) Hence they are not reported as "single nucleoTides, not in a chain of standard nucleotides". // CGR IN 2o3t CYCLIC GUANOSINE DIPHOSPHATE-RIBOSE (2 riboses) // Here the atoms in the 6-membered ring of guanine all have "A" appended, e.g. C2A, N3A. // One ribose has standard atom names. In the other, the atom names have "R" appended. // 6SY in 5khj Uridine-3',5'-cyclic monophosphate // Here the atom naming does not follow the convention of using prime (') on ribose atoms. // Numbering in uracil is non-standard. // 6SW in 5khh cyclic IMP // 75G in 5t3n cyclic-2-chloro-AMP // N6S in 3i59, (2S)-N6-(1-Methyl-2-phenylethyl)adenosine-3',5'-cyclic monophosphate // N6R in 3i59, (2R)-N6-(1-Methyl-2-phenylethyl)adenosine-3',5'-cyclic monophosphate NUCLEOTIDES, NOT PART OF A CHAIN, CYCLIC? These are correctly recognized as RNA. // CXR in 2o3q: Cyclic ADP-ribose // CV1 in 3zwy, 8-bromo cyclic ADP ribose // N1C in 2pgl, N1-CYCLIC INOSINE 5'-DIPHOSPHORIBOSE // CVR in 3u4i, Cyclic adenosine 5'-diphosphocarbocyclic ribose // C2E in 5exx, di-cyclic-GMP // CCC in 6dls, cyclic CMP 5' phosphate // C8R in 3u4h, 8 amino cyclic inosine diphospho ribose