Structural highlights
Function
RIR2_MOUSE Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (By similarity).
Publication Abstract from PubMed
The structure of peptide N-AcYTLDADF when bound to the large subunit of mouse ribonucleotide reductase has been elucidated by transfer NOE. This structure suggests a general design for type 1 RR inhibitors.
NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit.,Fisher A, Laub PB, Cooperman BS Nat Struct Biol. 1995 Nov;2(11):951-5. PMID:7583667[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Fisher A, Laub PB, Cooperman BS. NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit. Nat Struct Biol. 1995 Nov;2(11):951-5. PMID:7583667
