1agn

From Proteopedia

Jump to: navigation, search

X-RAY STRUCTURE OF HUMAN SIGMA ALCOHOL DEHYDROGENASE

Structural highlights

1agn is a 4 chain structure with sequence from Homo sapiens. The January 2001 RCSB PDB Molecule of the Month feature on Alcohol Dehydrogenase by David S. Goodsell is 10.2210/rcsb_pdb/mom_2001_1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Ligands:ACT, NAD, ZN
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ADH7_HUMAN Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

Contents


PDB ID 1agn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/1agn"
Personal tools