1d2z

Structural highlights

Function

KPEL_DROME Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll.^{[1] [2] [3] [4]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Shelton CA, Wasserman SA. pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo. Cell. 1993 Feb 26;72(4):515-25. PMID:8440018
2. ↑ Grosshans J, Bergmann A, Haffter P, Nusslein-Volhard C. Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo. Nature. 1994 Dec 8;372(6506):563-6. PMID:7527496 doi:http://dx.doi.org/10.1038/372563a0
3. ↑ Galindo RL, Edwards DN, Gillespie SK, Wasserman SA. Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos. Development. 1995 Jul;121(7):2209-18. PMID:7635064
4. ↑ Grosshans J, Schnorrer F, Nusslein-Volhard C. Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal. Mech Dev. 1999 Mar;81(1-2):127-38. PMID:10330490