1ffx

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TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX

Structural highlights

1ffx is a 5 chain structure with sequence from Bos taurus and Rattus norvegicus. The July 2014 RCSB PDB Molecule of the Month feature on Microtubules by David Goodsell is 10.2210/rcsb_pdb/mom_2014_7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.95Å
Ligands:GDP, GTP
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TBA1A_PIG Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Phosphoproteins of the stathmin family interact with the alphabeta tubulin heterodimer (tubulin) and hence interfere with microtubule dynamics. The structure of the complex of GDP-tubulin with the stathmin-like domain of the neural protein RB3 reveals a head-to-tail assembly of two tubulins with a 91-residue RB3 alpha helix in which each copy of an internal duplicated sequence interacts with a different tubulin. As a result of the relative orientations adopted by tubulins and by their alpha and beta subunits, the tubulin:RB3 complex forms a curved structure. The RB3 helix thus most likely prevents incorporation of tubulin into microtubules by holding it in an assembly with a curvature very similar to that of the depolymerization products of microtubules.

The 4 A X-ray structure of a tubulin:stathmin-like domain complex.,Gigant B, Curmi PA, Martin-Barbey C, Charbaut E, Lachkar S, Lebeau L, Siavoshian S, Sobel A, Knossow M Cell. 2000 Sep 15;102(6):809-16. PMID:11030624[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
39 reviews cite this structure
Dynamics and mechanics of the microtubule plus end.
Howard et al. (2003)
38 more
114 other articles
No citations found

See Also

References

  1. ↑ Gigant B, Curmi PA, Martin-Barbey C, Charbaut E, Lachkar S, Lebeau L, Siavoshian S, Sobel A, Knossow M. The 4 A X-ray structure of a tubulin:stathmin-like domain complex. Cell. 2000 Sep 15;102(6):809-16. PMID:11030624

Contents


PDB ID 1ffx

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OCA

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