1iqs

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Minimized average structure of MTH1880 from Methanobacterium Thermoautotrophicum

Structural highlights

1iqs is a 1 chain structure with sequence from Methanothermobacter thermautotrophicus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

O27908_METTH

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

MTH1880 is a hypothetical protein from Methanobacterium thermoautotrophicum, a target organism of structural genomics. The solution structure determined by NMR spectroscopy demonstrates a typical alpha + beta-fold found in many proteins with different functions. The molecular surface of the protein reveals a small, highly acidic pocket comprising loop B (Asp36, Asp37, Asp38), the end of beta2 (Glu39), and loop D (Ser57, Ser58, Ser61), indicating that the protein would have a possible cation binding site. The NMR resonances of several amino acids within the acidic binding pocket in MTH1880, shifted upon addition of calcium ion. This calcium binding motif and overall topology of MTH1880 differ from those of other calcium binding proteins. MTH1880 did not show a calcium-induced conformational change typical of calcium sensor proteins. Therefore, we propose that the MTH1880 protein contains a novel motif for calcium-specific binding, and may function as a calcium buffering protein.

Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum.,Lee CH, Jung JW, Yee A, Arrowsmith CH, Lee W Protein Sci. 2004 Apr;13(4):1148-54. PMID:15044740[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
2 reviews cite this structure
The impact of extremophiles on structural genomics (and vice versa).
Jenney et al. (2008)
1 more
0 other articles
No citations found

References

  1. ↑ Lee CH, Jung JW, Yee A, Arrowsmith CH, Lee W. Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum. Protein Sci. 2004 Apr;13(4):1148-54. PMID:15044740 doi:10.1110/ps.03472104

Contents


PDB ID 1iqs

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