Structural highlights
Function
SCX2_CENSC Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity). Induces immediate paralysis in crickets after injection, with a total paralysis occurring within 15-30 minutes and lasting for 1-2 hours. Is also lethal to vertebrate (chicks) when injected in very high dosages (more that 100 mg/kg).[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Babin DR, Watt DD, Goos SM, Mlejnek RV. Amino acid sequences of neurotoxic protein variants from the venom of Centruroides sculpturatus Ewing. Arch Biochem Biophys. 1974 Oct;164(2):694-706. PMID:4460885