1k8w

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Crystal structure of the E. coli pseudouridine synthase TruB bound to a T stem-loop RNA

Structural highlights

1k8w is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.85Å
Ligands:FHU, SO4
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TRUB_ECOLI Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Nurse K, Wrzesinski J, Bakin A, Lane BG, Ofengand J. Purification, cloning, and properties of the tRNA psi 55 synthase from Escherichia coli. RNA. 1995 Mar;1(1):102-12. PMID:7489483
  2. ↑ Gutgsell N, Englund N, Niu L, Kaya Y, Lane BG, Ofengand J. Deletion of the Escherichia coli pseudouridine synthase gene truB blocks formation of pseudouridine 55 in tRNA in vivo, does not affect exponential growth, but confers a strong selective disadvantage in competition with wild-type cells. RNA. 2000 Dec;6(12):1870-81. PMID:11142385

Contents


PDB ID 1k8w

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OCA

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