Crystal Structure of the Yeast Mitochondrial Holliday Junction Resolvase, Ydc2
Structural highlights
1kcf is a 2 chain structure with sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
CCE1_SCHPO Capable of resolving Holliday junctions. Specific for 4-way junctions. Seems to be important for the maintenance of mitochondrial DNA. Cleaves fixed junctions at the point of strand exchange. Cleaves after 5'-CT-3' and 5'-TT-3' sequences.[1][2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
↑ White MF, Lilley DM. Characterization of a Holliday junction-resolving enzyme from Schizosaccharomyces pombe. Mol Cell Biol. 1997 Nov;17(11):6465-71. PMID:9343409
↑ Doe CL, Osman F, Dixon J, Whitby MC. The Holliday junction resolvase SpCCE1 prevents mitochondrial DNA aggregation in Schizosaccharomyces pombe. Mol Gen Genet. 2000 Jul;263(6):889-97. PMID:10954073
