1n9w

Structural highlights

Function

SYDND_THET8 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn) with similar efficiencies. Reaction proceeds in two steps: aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Aminoacyl tRNA synthetase 3D structures

References

1. ↑ Becker HD, Roy H, Moulinier L, Mazauric MH, Keith G, Kern D. Thermus thermophilus contains an eubacterial and an archaebacterial aspartyl-tRNA synthetase. Biochemistry. 2000 Mar 28;39(12):3216-30. PMID:10727213
2. ↑ Becker HD, Reinbolt J, Kreutzer R, Giege R, Kern D. Existence of two distinct aspartyl-tRNA synthetases in Thermus thermophilus. Structural and biochemical properties of the two enzymes. Biochemistry. 1997 Jul 22;36(29):8785-97. PMID:9220965 doi:http://dx.doi.org/10.1021/bi970392v