1pvh

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Crystal structure of leukemia inhibitory factor in complex with gp130

Structural highlights

1pvh is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:IOD
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LIF_HUMAN LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Gp130 is a shared cell-surface signaling receptor for at least ten different hematopoietic cytokines, but the basis of its degenerate recognition properties is unknown. We have determined the crystal structure of human leukemia inhibitory factor (LIF) bound to the cytokine binding region (CHR) of gp130 at 2.5 A resolution. Strikingly, we find that the shared binding site on gp130 has an entirely rigid core, while the LIF binding interface diverges sharply in structure and chemistry from that of other gp130 ligands. Dissection of the LIF-gp130 interface, along with comparative studies of other gp130 cytokines, reveal that gp130 has evolved a "thermodynamic plasticity" that is relatively insensitive to ligand structure, to enable crossreactivity. These observations reveal a novel and alternative mechanism for degenerate recognition from that of structural plasticity.

Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130.,Boulanger MJ, Bankovich AJ, Kortemme T, Baker D, Garcia KC Mol Cell. 2003 Sep;12(3):577-89. PMID:14527405[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
23 reviews cite this structure
The molecular details of cytokine signaling via the JAK/STAT pathway.
Morris et al. (2018)
22 more
50 other articles
No citations found

See Also

References

  1. ↑ Boulanger MJ, Bankovich AJ, Kortemme T, Baker D, Garcia KC. Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. Mol Cell. 2003 Sep;12(3):577-89. PMID:14527405

Contents


PDB ID 1pvh

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