1wi4

Structural highlights

Function

STXB4_MOUSE Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose.^{[1] [2]}

Evolutionary Conservation

Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Syntaxin-binding protein

References

1. ↑ Min J, Okada S, Kanzaki M, Elmendorf JS, Coker KJ, Ceresa BP, Syu LJ, Noda Y, Saltiel AR, Pessin JE. Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes. Mol Cell. 1999 Jun;3(6):751-60. PMID:10394363
2. ↑ Saito T, Okada S, Yamada E, Ohshima K, Shimizu H, Shimomura K, Sato M, Pessin JE, Mori M. Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cell. J Biol Chem. 2003 Sep 19;278(38):36718-25. Epub 2003 Jul 9. PMID:12855681 doi:http://dx.doi.org/10.1074/jbc.M305114200