1xwd

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Crystal Structure of Human Follicle Stimulating Hormone Complexed with its Receptor

Structural highlights

1xwd is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.92Å
Ligands:BMA, NAG, SO4
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLHA_HUMAN

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Follicle-stimulating hormone (FSH) is central to reproduction in mammals. It acts through a G-protein-coupled receptor on the surface of target cells to stimulate testicular and ovarian functions. We present here the 2.9-A-resolution structure of a partially deglycosylated complex of human FSH bound to the extracellular hormone-binding domain of its receptor (FSHR(HB)). The hormone is bound in a hand-clasp fashion to an elongated, curved receptor. The buried interface of the complex is large (2,600 A2) and has a high charge density. Our analysis suggests that all glycoprotein hormones bind to their receptors in this mode and that binding specificity is mediated by key interaction sites involving both the common alpha- and hormone-specific beta-subunits. On binding, FSH undergoes a concerted conformational change that affects protruding loops implicated in receptor activation. The FSH-FSHR(HB) complexes form dimers in the crystal and at high concentrations in solution. Such dimers may participate in transmembrane signal transduction.

Structure of human follicle-stimulating hormone in complex with its receptor.,Fan QR, Hendrickson WA Nature. 2005 Jan 20;433(7023):269-77. PMID:15662415[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
73 reviews cite this structure
Structural diversity of G protein-coupled receptors and significance for drug discovery.
Lagerström et al. (2008)
72 more
202 other articles
No citations found

See Also

References

  1. ↑ Fan QR, Hendrickson WA. Structure of human follicle-stimulating hormone in complex with its receptor. Nature. 2005 Jan 20;433(7023):269-77. PMID:15662415 doi:10.1038/nature03206

Contents


PDB ID 1xwd

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OCA

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