1ycq

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XENOPUS LAEVIS MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF HUMAN P53

Structural highlights

1ycq is a 2 chain structure with sequence from Homo sapiens and Xenopus laevis. The July 2002 RCSB PDB Molecule of the Month feature on p53 Tumor Suppressor by David S. Goodsell is 10.2210/rcsb_pdb/mom_2002_7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MDM2_XENLA E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

Contents


PDB ID 1ycq

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OCA

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