2aoz

From Proteopedia

Crystal structure of the myotoxin-II from Atropoides nummifer venom

Structural highlights

2aoz is a 1 chain structure with sequence from Metlapilcoatlus nummifer. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.08Å
Ligands:	SO4
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PA2HB_METNM Snake venom phospholipase A2 homolog that lacks enzymatic activity, but has myotoxic and cytolytic activities.^[1]

Evolutionary Conservation

Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 angstroms resolution and the anion-binding site has been characterized.

Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom.,Murakami MT, Melo CC, Angulo Y, Lomonte B, Arni RK Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt, 5):423-6. Epub 2006 Apr 12. PMID:16682766^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

0 reviews cite this structure

Structural, functional, and bioinformatics studies reveal a new snake venom homologue phospholipase A₂ class.

dos et al. (2011)

-1 more

2 other articles

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References

↑ Angulo Y, Olamendi-Portugal T, Alape-Giron A, Possani LD, Lomonte B. Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A(2) homologue. Int J Biochem Cell Biol. 2002 Oct;34(10):1268-78. PMID:12127577
↑ Murakami MT, Melo CC, Angulo Y, Lomonte B, Arni RK. Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt, 5):423-6. Epub 2006 Apr 12. PMID:16682766 doi:http://dx.doi.org/10.1107/S1744309106010700

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

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PDB ID 2aoz

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2aoz

From Proteopedia

Crystal structure of the myotoxin-II from Atropoides nummifer venom

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

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